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Recombinant Human IL-34 (Carrier-free)

Recombinant Human IL-34 (Carrier-free)

Item no.	21-8684-U002
Manufacturer	Tonbo Biosciences
Amount	2 ug
Category	Oncology Neuroscience Neuroinflammation Molecular Targets for Neuroscience Neural Signaling Peptides & Proteins Recombinant Proteins By Organ Bone Cancer
Type	Proteins Recombinant
Specific against	Human
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Available
Description	IL-34 is secreted as a dimeric protein that is expressed in a variety of tissues, but is most abundant in the spleen. It shares the M-CSF Receptor, also known as CSF-1R and CD115, with CSF1 (also called M-CSF). IL-34 stimulates monocyte proliferation, promotes survival and proliferation of human peripheral blood monocytes, and stimulates macrophage colony formation by human bone marrow cells. It also stimulates phosphorylation of MAPK1/ERK2 and MAPK3/ERK1.
Alternative Names	C16orf77
Amino Acid Sequence	NEPLEMWPLT QNEECTVTGF LRDKLQYRSR LQYMKHYFPI NYKISVPYEG VFRIANVTRL QRAQVSEREL RYLWVLVSLS ATESVQDVLL EGHPSWKYLQ EVETLLLNVQ QGLTDVEVSP KVESVLSLLN APGPNLKLVR PKALLDNCFR VMELLYCSCC KQSSVLNWQD CEVPSPQSCS PEPSLQYAAT QLYPPPPWSP SSPPHSTGSV RPVRAQGEGL LPHHHHHHHH
Authenticity	Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity	Measured by its ability to induce secretion of MCP-1 from PBMCs.
Endotoxin Level	Endotoxin level is < 0.1 ng/µ g of protein ( < 1EU/µ g).
Molecular Mass	Recombinant human IL-34 is a 52.5 kDa homodimeric glycoprotein consisting of 460 amino acid residues, including a C-terminal His-Tag.
Protein Content	Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Research Areas	Bone, Skeletal, Cartilage; Cancer; Immune System; Inflammation; Proliferation
Purity	95%
Reconstitution	See Certificate of Analysis (COA) for lot specific reconstitution information.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 2 ug

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