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Recombinant Human IL-1RA (Carrier-free)

Recombinant Human IL-1RA (Carrier-free)

Item no.	21-7070-U020
Manufacturer	Tonbo Biosciences
Amount	20 ug
Category	Oncology Neuroscience Neuroinflammation Metabolism Diabetes Neural Signaling By Cell Type Carcinoma Peptides & Proteins Recombinant Proteins Obesity
Type	Proteins Recombinant
Specific against	Human
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Available
Description	Interleukin-1 receptor antagonist (IL-1RA) is a member of the IL-1 cytokine family of secreted proteins. It inhibits the activity of IL-1α and IL-1beta by competitively blocking their binding to type I and type II receptors. IL-1Ra is produced by corneal epithelial cells, monocytes, neutrophils, macrophages, and fibroblasts.
Alternative Names	IL-1RA, ICIL-1RA, IRAP, IL-1RN
Amino Acid Sequence	MRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ EDE
Authenticity	Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Bioactivity	Determined by its ability to inhibit the IL-1 alpha stimulation of murine D10S cell. The expected ED₅₀ is 20-40 ng/ml in the presence of 50 pg/ml of IL-1 alpha.
Endotoxin Level	Endotoxin level is < 0.1 ng/µ g of protein ( < 1EU/µ g).
Molecular Mass	Recombinant human IL-1Ra is a 17.2 kDa protein consisting of 153 amino acid residues.
Protein Content	Content Verified by UV Spectroscopy and/or SDS-PAGE gel.
Research Areas	Diabetes / Weight Regulation; Inflammation; Neurobiology
Purity	98%
Reconstitution	See Certificate of Analysis (COA) for lot specific reconstitution information.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 20 ug

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