Recombinant Human IGF-II (Carrier-free)

IGF-II (insulin-like growth factor II) is a member of a family of proteins involved in mediating growth and development. IGF-II expression is regulated by lactogen, is expressed in many cell and tissue types, and may have autocrine, paracrine and endocrine functions. IGF-II binds with higher affinity to IGF-R II than IGF-R I. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions. As with IGF-I, association with IGF binding proteins acts to extend the half-life of IGF-II and regulates receptor interaction.

AYRPSETLCG GELVDTLQFV CGDRGFYFSR PASRVSRRSR GIVEECCFRS CDLALLETYC ATPAKSE

The ED₅₀ was determined by a cell proliferation assay using FDC-P1 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 10⁵ units/mg.

Recombinant human IGF-II is a globular protein containing 67 amino acids and 3 intra-molecular disulfide bonds, and has a predicted molecular mass of approximately 7.47 kD.

Angiogenesis/Cardiovascular; Bone, Skeletal, Cartilage; Diabetes / Weight Regulation; Inflammation; Proliferation; Wound Healing

See Certificate of Analysis (COA) for lot specific reconstitution information.