Recombinant Human Heregulin beta-1 (Carrier-free)

Heregulin-1/Neuregulin (HRG1/NRG1) is one of four members of the Heregulin/Neuregulin family of cytokine growth factors that play important roles during development of the nervous system and the heart. A shared EGF-like domain interacts with ErbB3 and ErbB4 members of the ErbB family of receptors. Alternative splicing in the EGF-like domain of NRG1 results in α and beta isoforms. Heregulin beta-1 is a secreted protein that acts to modulate cell growth and differentiation. The HRG1-beta isoform displays neuroprotective properties and participates in development, survival, and metabolism in neuron and glial cells.

SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYKHLGIE FMEAE

The ED₅₀ was determined by the dose-dependent stimulation of the proliferation of human MCF-7 cells is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 10⁶

Recombinant human Heregulin beta-1 (HRG1-beta1) is a 7.5 kDa polypeptide consisting of only the EGF domain of Heregulin beta-1 (65 amino acid residues).

Angiogenesis/Cardiovascular; Apoptosis; Cancer; Proliferation; Stem Cells & Differentiation

See Certificate of Analysis (COA) for lot specific reconstitution information.