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PE Anti-Human CD4 (OKT4)

PE Anti-Human CD4 (OKT4)

Item no.	50-0048-T025
Manufacturer	Tonbo Biosciences
Amount	25 tests
Category	Oncology Neuroscience Neural Lineage Markers Neuroinflammation Aging & Neurological Disorders Antibodies Flow Cytometry Primary Antibodies By Organ Colorectal Cancer
Type	Antibody Monoclonal
Format	PE
Applications	FC
Clone	OKT4
Specific against	Human
Host	Mouse
Isotype	IgG2b kappa
Conjugate/Tag	PE
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Leu-3, T4
Similar products	Okt4
Available
Description	The OKT4 antibody reacts with human CD4, a 59 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta-2 domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4, and co-receptors CCR5 and CXCR4, may also be utilized by HIV-1 to enter T cells. Human CD4 is typically expressed on thymocytes, some mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells. The OKT4 antibody is widely used as a phenotypic marker for CD4 expression. It is cross-reactive with CD4 in several non-human species, including Chimpanzee, Cynomolgus and Rhesus. This antibody recognizes a different epitope, and thus does not block binding of, the alternative Anti-Human CD4 antibody clone RPA-T4 (Reinherz EL, et al. 1979. Proc. Natl. Acad. Sci. 76:4061-4065)
Alternative Names	Leu-3, T4
Gene ID	920
Citations	Chen CY, Huang D, Yao S, Halliday L, Zeng G, Wang RC and Chen ZW. 2012. J. Immunol. 188:4278-4288. (in vivo depletion - macaque) Bagnara D, Kaufman MS, Calissano C, et al. 2011. Blood. 117: 5463-5472. (in vivo depletion) Ciczora Y, Callens N, Seron K, Rouille Y, and Dubuisson J. 2010. J. Gen. Virol. 91:404-414. (Immunofluorescence microscopy; Western Blot) Nguyen V, Cao L, Lin JT, Hung N, Ritz A, Yu K, Jianu R, Ulin SP, Raphael BJ, Laidlaw DH, Brossay L, and Salomon AR. 2009. Mol. Cell. Proteomics. 8: 2418-2431. (in vitro activation) daSilva LLP, Sougrat R, Burgos PV, Janvier K, Mattera R, and Bonifacino JS. 2009. J. Virol. 83: 6578-6590 (Immunoprecipitation) Balla-Jhagjhoorsingh S, Koopman G, Mooij P, Haaksma TGM, Teeuwsen VJP, Bontrop RE, and Heeney JL. 1999. J. Immunol. 162: 2308-2314. (Immunocytochemistry /Immunofluorescence microscopy - Chimpanzee) Bour S, Boulerice F, and Wainberg MA. 1991. J. Virol. 65(12) : 6387-6396. (Immunoprecipitation) Watanabe M, Ringler DJ, Fultz PN, MacKey JJ, Boyson JE, Levine CG, and Letvin NL. 1991. J. Virol. 65: 3344-3348. (Flow cytometry - Chimpanzee)
Cross Reactivity	Chimpanzee, Cynomolgus, Rhesus

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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