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PF 429242

PF 429242

Item no.	TMO-T4317-10mM
Manufacturer	TargetMol
CASRN	947303-87-9
Amount	10mM*1mL(inDMSO)
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Citations	1.Monnerie H, Romer M, Jensen BK, Millar JS, Jordan-Sciutto KL, Kim SF, Grinspan JB. Reduced sterol regulatory element-binding protein (SREBP) processing through site-1 protease (S1P) inhibition alters oligodendrocyte differentiation in vitro. J Neurochem.
Smiles	O=C(C2=CC=C(CN(CC)CC)C=C2)N(CCC3=CC=CC=C3OC)[CH]1CCNC1.Cl.Cl
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	NPC1L1 inhibitor
Available
Bioactivity	PF-429242 is a competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease (IC50 = 0.175 uM). It is selective for site 1 protease against a panel of serine proteases. PF-429242 inhibits rate of cholesterol synthesis in CHO cells (IC50 = 0.53 uM).
MolWt	482, 49
Pathways	Membrane transporter/Ion channel
Receptor	SREBP1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10mM*1mL(inDMSO)

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