GW4869

Item no.	TMO-T3640-10mM
Manufacturer	TargetMol
CASRN	6823-69-4
Amount	10 mM x 1 mL (in DMSO)
Quantity options	100 mg 10 mM x 1 mL (in DMSO) 10 mg 25 mg 2 mg 50 mg 5 mg
Category	Oncology Metabolism Diabetes Glucose Homeostasis Reagents & Chemicals Molecules By Organ Breast Cancer
Type	Molecules
Specific against	other
Citations	1. Marchesini, N., et al. 2003. J. Biol. Chem. In press.
Smiles	Cl.Cl.O=C(Nc1ccc(cc1)C1=NCCN1)\C=C\c1ccc(\C=C\C(=O)Nc2ccc(cc2)C2=NCCN2)cc1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	GW 4869, GW554869A, GW69A
Shipping condition	Cool pack
Available
Manufacturer - Targets	Phospholipase
Shipping Temperature	cool pack
Storage Conditions	-20°
Molecular Weight	577, 5
Description	GW4869 (GW69A) is a selective and non-competitive inhibitor of neutral sphingomyelinase N-SMase (IC50=1 μM). GW4869 also inhibits exosome synthesis/release and is commonly used in exosome-related studies.
Bioactivity	A cell-permeable, symmetrical dihydroimidazolo-amide compound that acts as a potent, specific, non-competitive inhibitor of N-SMase (neutral sphingomyelinase) [IC50 = ca. 1 uM, rat brain; Km for sphingomyelin ca.13 uM]. Does not inhibit human A-SMase (acid sphingomyelinase) even at 150 uM. Weakly inhibits the activities of bovine protein phosphatase 2A and mammalian lyso-PAF PLC, while no inhibition is observed for bacterial phosphatidylcholine-specific PLC. Reported to offer complete protection against TNF-alpha or diamine-induced cell death in MCF7 breast Y cells at 20 uM. Does not modify the intracellular glutathione levels or interfere with TNF-alpha or diamine-mediated signaling effects.
Pathways	Metabolism
Receptor	neutral sphingomyelinase

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

TMO-T3640-10mM-datasheet.pdf

Request safety datasheet

Simple Order Order Subscription

Amount: 10 mM x 1 mL (in DMSO)

available

Request delivery time