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AZD1283

AZD1283

Item no.	TMO-T3536-5mg
Manufacturer	TargetMol
CASRN	919351-41-0
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Citations	1. Bach P,et al. Lead optimization of ethyl 6-aminonicotinate acyl sulfonamides as antagonists of the P2Y12 receptor. separation of the antithrombotic effect and bleeding for candidate drug AZD1283. J Med Chem. 2013 Sep 12;56(17):7015-24.
Smiles	CCOC(=O)c1c(nc(c(c1)C#N)N1CCC(CC1)C(=O)NS(=O)(=O)Cc1ccccc1)C
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	P2 Receptor inhibitor
Available
Short Description	AZD1283 is an effective P2Y12 receptor antagonist (EC50: 3.0 ug/kg/min, binding IC50: 11 nM). AZD1283 dose-dependently induced increases in blood flow and inhibition of ADP-induced platelet aggregation with antithrombotic ED50 values of 3.0 and 10 μg/kg/min, respectively. The doses induced the increase in bleeding time at 33 and 100 μg/kg/min for 3- and 13-fold, respectively. Thus, the therapeutic index (TI) was ≥10 for both compounds.
Shipping	cool pack
Storage	-20°
Molecular Weight	470, 54
Pathway	Neuroscience\|\|\|GPCR/G Protein
Target	P2Y Receptor

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 5mg

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Delivery expected until 9/27/2024

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