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Nolatrexed dihydrochloride

Nolatrexed dihydrochloride

Item no.	TMO-T2627-2mg
Manufacturer	TargetMol
CASRN	152946-68-4
Amount	2mg
Category	Metabolism Cholesterol & Lipid Metabolism Enzymes Other Fatty Acid Enzymes Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Citations	1. Hughes AN, et al. Br J Y. 2000 May;82(9):1519-27.
Smiles	CC1=C(SC2=CC=NC=C2)C2=C(NC(N)=NC2=O)C=C1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	DNA/RNA Synthesis inhibitor
Available
Bioactivity	Nolatrexed Dihydrochloride is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatrexed occupies the folate binding site of thymidylate synthase, resulting in inhibition of thymidylate synthase activity and thymine nucleotide synthesis with subsequent inhibition of DNA replication, DNA damage, S-phase cell cycle arrest, and caspase-dependent apoptosis. This agent also exhibits radiosensitizing activity.
MolWt	357, 26
Pathways	DNA Damage/DNA Repair
Receptor	Thymidylate synthase

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Amount: 2mg

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Delivery expected until 9/27/2024

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