Item no. |
STJ116768-100 |
Manufacturer |
St John's Laboratory
|
Amount |
100ul |
Category |
|
Type |
Antibody Polyclonal |
Applications |
WB |
Specific against |
Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Anti-Egl Nine Homolog 1 antibody</br>Anti-Hypoxia-Inducible Factor Prolyl Hydroxylase 2 antibody</br>Anti-Hif-Ph2 antibody</br>Anti-Hif-Prolyl Hydroxylase 2 antibody</br>Anti-Hph-2 antibody</br>Anti-Prolyl Hydroxylase Domain-Containing Protein 2 antibody< |
Similar products |
Anti-Egl Nine Homolog 1 antibodyAnti-Hypoxia-Inducible Factor Prolyl Hydroxylase 2 antibodyAnti-Hif-Ph2 antibodyAnti-Hif-Prolyl Hydroxylase 2 antibodyAnti-Hph-2 antibodyAnti-Prolyl Hydroxylase Domain-Containing Protein 2 antibody< |
Available |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification |
Affinity purification |
Uniprot ID |
Q9GZT9 |
Storage |
Store at-20° C and avoid freeze-thaw cycles. |
Description |
The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3). |
Gene ID |
|
Gene symbol |
|
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-426 of human EGLN1 (NP_071334. 1). |
Short Description |
Rabbit polyclonal against EGLN1 |
Tissue specificity |
widely expressed with highest levels in skeletal muscle and heart, moderate levels in pancreas, brain (dopaminergic neurons of adult and fetal substantia nigra) and kidney, and lower levels in lung and liver. widely expressed with highest levels in brain, kidney and adrenal gland. Expressed in cardiac myocytes, aortic endothelial cells and coronary artery smooth muscle..expressed in adult and fetal heart, brain, liver, lung, skeletal muscle and kidney. Also expressed in placenta. Highest levels in adult heart, brain, lung and liver and fetal brain, heart spleen and skeletal muscle. |
Cellular localization |
CytoplasmNucleusMainly CytoplasmicShuttles Between The Nucleus And CytoplasmNuclear Export Requires Functional Xpo1 |
Molecular weight |
Calculated: 36kDa/43kDa/46kDa. Observed: 46kDa |
Dilution range |
WB 1:500-1:2000 |
Alternative names |
Anti-Egl Nine Homolog 1 antibodyAnti-Hypoxia-Inducible Factor Prolyl Hydroxylase 2 antibodyAnti-Hif-Ph2 antibodyAnti-Hif-Prolyl Hydroxylase 2 antibodyAnti-Hph-2 antibodyAnti-Prolyl Hydroxylase Domain-Containing Protein 2 antibodyAnti-Phd2 antibodyAnti-Sm-20 antibodyAnti-EGLN1 C1orf12 PNAS-118 PNAS-137 antibody |
Protein name |
Egl Nine Homolog 1Hypoxia-Inducible Factor Prolyl Hydroxylase 2Hif-Ph2Hif-Prolyl Hydroxylase 2Hph-2Prolyl Hydroxylase Domain-Containing Protein 2Phd2Sm-20 |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
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Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.