Anti-SIRT2 antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Q8IXJ6

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene.

SIRT2

Rabbit polyclonal against SIRT2

Nucleus
Cytoplasm
Perinuclear Region
Cytoskeleton
Microtubule Organizing Center
Centrosome
Centriole
Spindle
Midbody
Chromosome
Perikaryon
Cell Projection
Growth Cone
Myelin Membrane
Deacetylates Foxo3 In The Cytoplasm
Colocalizes With Plp1 In Internodal Regions
At Paranodal Axoglial Junction And Schmidt-Lanterman Incisures Of Myelin Sheat
Colocalizes With Cdk5r1 In The Perikaryon
Neurites And Growth Cone Of Hippocampal Neurons
Colocalizes With Alpha-Tubulin In Neuronal Growth Cone
Localizes In The Cytoplasm And Nucleus Of Germinal Vesicle (Gv) Stage Oocytes
Colocalizes With Alpha-Tubulin On The Meiotic Spindle As The Oocytes Enter Into Metaphase
And Also During Meiotic Anaphase And Telophase
Especially With The Midbody
Colocalizes With Pard3 In Internodal Region Of Axons
Colocalizes With Acetylated Alpha-Tubulin In Cell Projection Processes During Primary Oligodendrocyte Precursor (Olp) Differentiation
Localizes In The Cytoplasm During Most Of The Cell Cycle Except In The G2/M Transition And During Mitosis
Where It Is Localized In Association With Chromatin And Induces Deacetylation Of Histone At 'Lys-16' (H4k16ac)
Colocalizes With Kmt5a At Mitotic Foci
Colocalizes With Cdk1 At Centrosome During Prophase And Splindle Fibers During Metaphase
Colocalizes With Aurora Kinase Aurka At Centrosome During Early Prophase And In The Centrioles And Growing Mitotic Spindle Throughout Metaphase
Colocalizes With Aurora Kinase Aurkb During Cytokinesis With The Midbody
Colocalizes With Microtubules
Detected In Perinuclear Foci That May Be Aggresomes Containing Misfolded
Ubiquitinated Proteins
Shuttles Between The Cytoplasm And The Nucleus Through The Crm1 Export Pathway
Colocalizes With Ep300 In The Nucleus
Translocates To The Nucleus And Chromatin Upon Bacterium Listeria Monocytogenes Infection In Interphase Cells
Isoform 1: Cytoplasm
Predominantly Localized In The Cytoplasmic
Isoform 2: Cytoplasm
Isoform 5: Cytoplasm
Predominantly Localized In The Nucleus

WB 1:500-1:2000

Nad-Dependent Protein Deacetylase Sirtuin-2
Regulatory Protein Sir2 Homolog 2
Sir2-Like Protein 2

SIR2_HUMAN