Item no. |
STJ29241-50 |
Manufacturer |
St John's Laboratory
|
Amount |
50ul |
Category |
|
Type |
Antibody Polyclonal |
Applications |
WB |
Specific against |
Human |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Anti-Re1-Silencing Transcription Factor antibody</br>Anti-Neural-Restrictive Silencer Factor antibody</br>Anti-X2 Box Repressor antibody</br>Anti-REST NRSF XBR antibody |
Similar products |
Anti-Re1-Silencing Transcription Factor antibodyAnti-Neural-Restrictive Silencer Factor antibodyAnti-X2 Box Repressor antibodyAnti-REST NRSF XBR antibody |
Available |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification |
Affinity purification |
Uniprot ID |
Q13127 |
Storage |
Store at-20° C and avoid freeze-thaw cycles. |
Description |
This gene encodes a transcriptional repressor that represses neuronal genes in non-neuronal tissues. It is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regular of neurogenesis. Alternatively spliced transcript variants have been described |
Gene ID |
|
Gene symbol |
|
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 760-1060 of human REST (NP_001180437. 1). |
Short Description |
Rabbit polyclonal against REST |
Tissue specificity |
Expressed in neurons of the prefrontal cortex, in hippocampal pyramidal neurons, dentate gyrus granule neurons and cerebellar Purkinje and granule neurons (at protein level). Expressed in dopaminergic neurons of the substantia nigra (at protein level). Expressed in neural progenitor cells (at protein level). In patients suffering from Alzheimer disease, frontotemporal dementia or dementia with Lewy bodies, decreased nuclear levels have been observed in neurons of the prefrontal cortex and the hippocampus, but not in neurons of the dentate gyrus and cerebellum (at protein level). In patients with Parkinson disease or dementia with Lewy bodies, decreased nuclear levels have been observed in dopaminergic neurons and in cortical neurons and localization to Lewy bodies and pale bodies was detected (at protein level). Expressed at higher levels in weakly invasive breast cancer cell lines and at lower levels in highly invasive breast cancer lines (at protein level). Ubiquitous. Expressed at higher levels in the tissues of the lymphocytic compartment, including spleen, thymus, peripheral blood lymphocytes and ovary. |
Cellular localization |
NucleusCytoplasmColocalizes With Zfp90 In The NucleusIn Response To HypoxiaThere Is A More Pronounced Increase In Levels In The Nucleus As Compared To The CytoplasmIn Aging NeuronsIncreased Levels In The Nucleus As Compared To The CytoplasmIsoform 2: CytoplasmIsoform 3: NucleusIsoform 4: Cytoplasm |
Molecular weight |
Calculated: 35kDa/36kDa/119kDa/121kDa. Observed: 150kDa |
Dilution range |
WB 1:500-1:2000 |
Alternative names |
Anti-Re1-Silencing Transcription Factor antibodyAnti-Neural-Restrictive Silencer Factor antibodyAnti-X2 Box Repressor antibodyAnti-REST NRSF XBR antibody |
Protein name |
Re1-Silencing Transcription FactorNeural-Restrictive Silencer FactorX2 Box Repressor |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.