Anti-GHR Antibody

This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.

GHR antibody
Growth hormone receptor antibody
GH receptor antibody
Somatotropin receptor antibody
GHR antibody

Unconjugated

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

GHR

IgG

For Research Use Only (RUO).

Store at -20C. Avoid freeze / thaw cycles.

Expressed in various tissues with high expression in liver and skeletal muscle, Isoform 4 is predominantly expressed in kidney, bladder, adrenal gland and brain stem, Isoform 1 expression in placenta is predominant in chorion and decidua, Isoform 4 is highly expressed in placental villi, Isoform 2 is expressed in lung, stomach and muscle, Low levels in liver