Anti-MKKS antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Q9NPJ1

This gene encodes a protein which shares sequence similarity with other members of the type II chaperonin family. The encoded protein is a centrosome-shuttling protein and plays an important role in cytokinesis. This protein also interacts with other type II chaperonin members to form a complex known as the BBSome, which involves ciliary membrane biogenesis. This protein is encoded by a downstream open reading frame (dORF). Several upstream open reading frames (uORFs) have been identified, which repress the translation of the dORF, and two of which can encode small mitochondrial membrane proteins. Mutations in this gene have been observed in patients with Bardet-Biedl syndrome type 6, also known as McKusick-Kaufman syndrome. Alternative splicing results in multiple transcript variants.

MKKS

Rabbit polyclonal against MKKS

Cytoplasm
Cytoskeleton
Microtubule Organizing Center
Centrosome
Cytosol
Nucleus
The Majority Of The Protein Resides Within The Pericentriolar Material (Pcm)
A Proteinaceous Tube Surrounding Centrioles
During Interphase
The Protein Is Confined To The Lateral Surfaces Of The Pcm But During Mitosis It Relocalizes Throughout The Pcm And Is Found At The Intercellular Bridge
The Mkss Protein Is Highly Mobile And Rapidly Shuttles Between The Cytosol And Centrosome

WB 1:200-1:2000

Mckusick-Kaufman/Bardet-Biedl Syndromes Putative Chaperonin
Bardet-Biedl Syndrome 6 Protein

MKKS_HUMAN