Item no. |
STJ116018-100 |
Manufacturer |
St John's Laboratory
|
Amount |
100ul |
Category |
|
Type |
Antibody Polyclonal |
Applications |
WB, IF |
Specific against |
Human |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Anti-E3 Ubiquitin-Protein Ligase Rnf8 antibody</br>Anti-Hrnf8 antibody</br>Anti-Ring Finger Protein 8 antibody</br>Anti-Ring-Type E3 Ubiquitin Transferase Rnf8 antibody</br>Anti-RNF8 KIAA0646 antibody |
Similar products |
Anti-E3 Ubiquitin-Protein Ligase Rnf8 antibodyAnti-Hrnf8 antibodyAnti-Ring Finger Protein 8 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Rnf8 antibodyAnti-RNF8 KIAA0646 antibody |
Available |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification |
Affinity purification |
Uniprot ID |
O76064 |
Storage |
Store at-20° C and avoid freeze-thaw cycles. |
Description |
The protein encoded by this gene contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. This protein is also known to play a role in the DNA damage response and depletion of this protein causes cell growth inhibition and cell cycle arrest. Alternative splicing results in multiple transcript variants. |
Gene ID |
|
Gene symbol |
|
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human RNF8 (NP_003949. 1). |
Short Description |
Rabbit polyclonal against RNF8 |
Tissue specificity |
Ubiquitous. In fetal tissues, highest expression in brain, thymus and liver. In adult tissues, highest levels in brain and testis, lowest levels in peripheral blood cells. |
Cellular localization |
NucleusCytoplasmMidbodyChromosomeTelomereRecruited At Uncapped TelomeresFollowing Dna DamageSuch As Double-Strand BreaksRecruited To The Sites Of DamageDuring ProphaseConcomitant With Nuclear Envelope BreakdownLocalizes Throughout The CellWith A Dotted PatternIn TelophaseAgain In The Nucleus And Also With A Discrete Dotted Pattern In The CytoplasmIn Late Telophase And During CytokinesisLocalizes In The Midbody Of The Tubulin Bridge Joining The Daughter CellsDoes Not Seem To Be Associated With Condensed Chromosomes At Any Time During The Cell CycleDuring SpermatogenesisSequestered In The Cytoplasm By Piwil1: Rnf8 Is Released Following Ubiquitination And Degradation Of Piwil1 |
Molecular weight |
Calculated: 10kDa/50kDa/55kDa. |
Dilution range |
WB 1:500-1:2000 IF 1:50-1:200 |
Alternative names |
Anti-E3 Ubiquitin-Protein Ligase Rnf8 antibodyAnti-Hrnf8 antibodyAnti-Ring Finger Protein 8 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Rnf8 antibodyAnti-RNF8 KIAA0646 antibody |
Protein name |
E3 Ubiquitin-Protein Ligase Rnf8Hrnf8Ring Finger Protein 8Ring-Type E3 Ubiquitin Transferase Rnf8 |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
|
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.