Anti-HYAL3 antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

O43820

This gene encodes a member of the hyaluronidase family. Hyaluronidases are endoglycosidase enzymes that degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. The regulated turnover of hyaluronan plays a critical role in many biological processes including cell proliferation, migration and differentiation. The encoded protein may also play an important role in sperm function. This gene is one of several related genes in a region of chromosome 3p21. 3 associated with tumor suppression, and the expression of specific transcript variants may be indicative of tumor status. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and some isoforms may lack hyaluronidase activity. This gene overlaps and is on the same strand as N-acetyltransferase 6 (GCN5-related), and some transcripts of each gene share a portion of the first exon.

HYAL3

Rabbit polyclonal against HYAL3

Secreted
Cell Membrane
Cytoplasmic Vesicle
Secretory Vesicle
Acrosome
Endoplasmic Reticulum
Early Endosome
Mostly Present In Low-Density Vesicles
Low Levels In Higher Density Vesicles Of Late Endosomes And Lysosomes
Localized In Punctate Cytoplasmic Vesicles And In Perinuclear Structures
But Does Not Colocalize With Lamp1
Localized On The Plasma Membrane Over The Acrosome And On The Surface Of The Midpiece Of The Sperm Tail

IF 1:50-1:100

Hyaluronidase-3
Hyal-3
Hyaluronoglucosaminidase-3
Lung Carcinoma Protein 3
Luca-3

HYAL3_HUMAN