Anti-ASPH antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Q12797

This gene is thought to play an important role in calcium homeostasis. The gene is expressed from two promoters and undergoes extensive alternative splicing. The encoded set of proteins share varying amounts of overlap near their N-termini but have substantial variations in their C-terminal domains resulting in distinct functional properties. The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the epidermal growth factor (EGF)-like domains of some proteins, including protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. Other isoforms differ primarily in the C-terminal sequence and lack the hydroxylase domain, and some have been localized to the endoplasmic and sarcoplasmic reticulum. Some of these isoforms are found in complexes with calsequestrin, triadin, and the ryanodine receptor, and have been shown to regulate calcium release from the sarcoplasmic reticulum. Some isoforms have been implicated in metastasis.

ASPH

Rabbit polyclonal against ASPH

Isoform 1: Endoplasmic Reticulum Membrane
Single-Pass Type Ii Membrane Protein
Isoform 4: Sarcoplasmic Reticulum Membrane
Isoform 8: Endoplasmic Reticulum Membrane

WB 1:500-1:2000

Aspartyl/Asparaginyl Beta-Hydroxylase
Aspartate Beta-Hydroxylase
Asp Beta-Hydroxylase
Peptide-Aspartate Beta-Dioxygenase

ASPH_HUMAN