Item no. |
STJ115119-50 |
Manufacturer |
St John's Laboratory
|
Amount |
50ul |
Category |
|
Type |
Antibody Polyclonal |
Applications |
WB |
Specific against |
Human |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Anti-Aspartyl/Asparaginyl Beta-Hydroxylase antibody</br>Anti-Aspartate Beta-Hydroxylase antibody</br>Anti-Asp Beta-Hydroxylase antibody</br>Anti-Peptide-Aspartate Beta-Dioxygenase antibody</br>Anti-ASPH BAH antibody |
Similar products |
Anti-Aspartyl/Asparaginyl Beta-Hydroxylase antibodyAnti-Aspartate Beta-Hydroxylase antibodyAnti-Asp Beta-Hydroxylase antibodyAnti-Peptide-Aspartate Beta-Dioxygenase antibodyAnti-ASPH BAH antibody |
Available |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification |
Affinity purification |
Uniprot ID |
Q12797 |
Storage |
Store at-20° C and avoid freeze-thaw cycles. |
Description |
This gene is thought to play an important role in calcium homeostasis. The gene is expressed from two promoters and undergoes extensive alternative splicing. The encoded set of proteins share varying amounts of overlap near their N-termini but have substantial variations in their C-terminal domains resulting in distinct functional properties. The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the epidermal growth factor (EGF)-like domains of some proteins, including protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. Other isoforms differ primarily in the C-terminal sequence and lack the hydroxylase domain, and some have been localized to the endoplasmic and sarcoplasmic reticulum. Some of these isoforms are found in complexes with calsequestrin, triadin, and the ryanodine receptor, and have been shown to regulate calcium release from the sarcoplasmic reticulum. Some isoforms have been implicated in metastasis. |
Gene ID |
|
Gene symbol |
|
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 111-270 of human ASPH (NP_001158227. 1). |
Short Description |
Rabbit polyclonal against ASPH |
Tissue specificity |
Isoform 1 is detected in all tissues tested. Isoform 8 is mainly expressed in pancreas, heart, brain, kidney and liver. Isoform 8 is expressed in kidney (at protein level). |
Cellular localization |
Isoform 1: Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane ProteinIsoform 4: Sarcoplasmic Reticulum MembraneIsoform 8: Endoplasmic Reticulum Membrane |
Molecular weight |
Calculated: 21-34kDa/83-85kDa. Observed: 86kDa |
Dilution range |
WB 1:500-1:2000 |
Alternative names |
Anti-Aspartyl/Asparaginyl Beta-Hydroxylase antibodyAnti-Aspartate Beta-Hydroxylase antibodyAnti-Asp Beta-Hydroxylase antibodyAnti-Peptide-Aspartate Beta-Dioxygenase antibodyAnti-ASPH BAH antibody |
Protein name |
Aspartyl/Asparaginyl Beta-HydroxylaseAspartate Beta-HydroxylaseAsp Beta-HydroxylasePeptide-Aspartate Beta-Dioxygenase |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
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Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.