Item no. |
STJ113761-50 |
Manufacturer |
St John's Laboratory
|
Amount |
50ul |
Category |
|
Type |
Antibody Polyclonal |
Applications |
WB |
Specific against |
Human |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Anti-Breast Cancer Type 1 Susceptibility Protein antibody</br>Anti-Ring Finger Protein 53 antibody</br>Anti-Ring-Type E3 Ubiquitin Transferase Brca1 antibody</br>Anti-BRCA1 RNF53 antibody |
Similar products |
Anti-Breast Cancer Type 1 Susceptibility Protein antibodyAnti-Ring Finger Protein 53 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Brca1 antibodyAnti-BRCA1 RNF53 antibody |
Available |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification |
Affinity purification |
Uniprot ID |
P38398 |
Storage |
Store at-20° C and avoid freeze-thaw cycles. |
Description |
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. |
Gene ID |
|
Gene symbol |
|
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 400-699 of human BRCA1 (NP_009230. 2). |
Short Description |
Rabbit polyclonal against BRCA1 |
Tissue specificity |
Isoform 1 and isoform 3 are widely expressed. Isoform 3 is reduced or absent in several breast and ovarian cancer cell lines. |
Cellular localization |
NucleusChromosomeCytoplasmLocalizes At Sites Of Dna Damage At Double-Strand Breaks (Dsbs)Recruitment To Dna Damage Sites Is Mediated By Abraxas1 And The Brca1-A ComplexTranslocated To The Cytoplasm During Uv-Induced ApoptosisIsoform 3: CytoplasmIsoform 5: Cytoplasm |
Molecular weight |
Calculated: 7kDa/78-85kDa/202-210kDa. Observed: 280kDa |
Dilution range |
WB 1:500-1:2000 |
Alternative names |
Anti-Breast Cancer Type 1 Susceptibility Protein antibodyAnti-Ring Finger Protein 53 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Brca1 antibodyAnti-BRCA1 RNF53 antibody |
Protein name |
Breast Cancer Type 1 Susceptibility ProteinRing Finger Protein 53Ring-Type E3 Ubiquitin Transferase Brca1 |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
|
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.