Item no. |
STJ112099-50 |
Manufacturer |
St John's Laboratory
|
Amount |
50ul |
Category |
|
Type |
Antibody Polyclonal |
Applications |
WB |
Specific against |
Human |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 5.1 |
32160702 |
ECLASS 6.1 |
32160702 |
ECLASS 8.0 |
32160702 |
ECLASS 9.0 |
32160702 |
ECLASS 10.0.1 |
32160702 |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Anti-Complement Receptor Type 1 antibody</br>Anti-C3b/C4b Receptor antibody</br>Anti-Cd Antigen Cd35 antibody</br>Anti-CR1 C3BR antibody |
Similar products |
Anti-Complement Receptor Type 1 antibodyAnti-C3b/C4b Receptor antibodyAnti-Cd Antigen Cd35 antibodyAnti-CR1 C3BR antibody |
Available |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification |
Affinity purification |
Uniprot ID |
P17927 |
Storage |
Store at-20° C and avoid freeze-thaw cycles. |
Description |
This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. |
Gene ID |
|
Gene symbol |
|
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 420-550 of human CR1 (NP_000642. 3). |
Short Description |
Rabbit polyclonal against CR1 |
Tissue specificity |
Present on erythrocytes, a subset of T cells, mature B cells, follicular dendritic cells, monocytes and granulocytes. |
Cellular localization |
MembraneSingle-Pass Type I Membrane Protein |
Molecular weight |
Calculated: 223kDa. Observed: 270kDa |
Dilution range |
WB 1:500-1:2000 |
Alternative names |
Anti-Complement Receptor Type 1 antibodyAnti-C3b/C4b Receptor antibodyAnti-Cd Antigen Cd35 antibodyAnti-CR1 C3BR antibody |
Protein name |
Complement Receptor Type 1C3b/C4b ReceptorCd Antigen Cd35 |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
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Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.