Anti-NUP98 antibody

Monoclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

P52948

Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nucleoporin gene family and encodes a 186 kDa precursor protein that undergoes autoproteolytic cleavage to generate a 98 kDa nucleoporin and 96 kDa nucleoporin. The 98 kDa nucleoporin contains a Gly-Leu-Phe-Gly (GLGF) repeat domain and participates in many cellular processes, including nuclear import, nuclear export, mitotic progression, and regulation of gene expression. The 96 kDa nucleoporin is a scaffold component of the NPC. Proteolytic cleavage is important for targeting of the proteins to the NPC. Translocations between this gene and many other partner genes have been observed in different leukemias. Rearrangements typically result in chimeras with the N-terminal GLGF domain of this gene to the C-terminus of the partner gene. Alternative splicing results in multiple transcript variants encoding different isoforms, at least two of which are proteolytically processed. Some variants lack the region that encodes the 96 kDa nucleoporin.

NUP98

Mouse monoclonal against NUP98

Calculated: 96kDa/97kDa/186kDa/187kDa/195kDa/197kDa. Observed: 110kDa

Anti-Nuclear Pore Complex Protein Nup98-Nup96 Cleaved Into-Nuclear Pore Complex Protein Nup98 antibody
Anti-98 Kda Nucleoporin antibody
Anti-Nucleoporin Nup98 antibody
Anti-Nup98-Nuclear Pore Complex Protein Nup96 antibody
Anti-96 Kda Nucleoporin antibody
Anti-Nucleoporin Nup96 antibody
Anti-Nup96 antibody
Anti-NUP98 ADAR2 antibody

FOR RESEARCH USE ONLY (RUO).