Anti-DHCR7 antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Q9UBM7

This gene encodes an enzyme that removes the C(7-8) double bond in the B ring of sterols and catalyzes the conversion of 7-dehydrocholesterol to cholesterol. This gene is ubiquitously expressed and its transmembrane protein localizes to the endoplasmic reticulum membrane and nuclear outer membrane. Mutations in this gene cause Smith-Lemli-Opitz syndrome (SLOS); a syndrome that is metabolically characterized by reduced serum cholesterol levels and elevated serum 7-dehydrocholesterol levels and phenotypically characterized by mental retardation, facial dysmorphism, syndactyly of second and third toes, and holoprosencephaly in severe cases to minimal physical abnormalities and near-normal intelligence in mild cases. Alternative splicing results in multiple transcript variants that encode the same protein.

DHCR7

Rabbit polyclonal against DHCR7

Endoplasmic Reticulum Membrane
Multi-Pass Membrane Protein

WB 1:500-1:2000

7-Dehydrocholesterol Reductase
7-Dhc Reductase
Delta7-Sterol Reductase
Sterol Delta(7-Reductase
Sterol Reductase Sr-2

DHCR7_HUMAN