Anti-Phospho-CDK6-(Y24) antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Q00534

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified.

CDK6

Rabbit polyclonal against Phospho-CDK6-(Y24)

Cytoplasm
Nucleus
Cell Projection
Ruffle
Cytoskeleton
Microtubule Organizing Center
Centrosome
Localized To The Ruffling Edge Of Spreading Fibroblasts
Kinase Activity Only In Nucleus
Localized To The Cytosol Of Neurons And Showed Prominent Staining Around Either Side Of The Nucleus
Present In The Cytosol And In The Nucleus In Interphase Cells And At The Centrosome During Mitosis From Prophase To Telophase

WB 1:500-1:2000 IHC 1:50-1:100 IF 1:100-1:200

Cyclin-Dependent Kinase 6
Cell Division Protein Kinase 6
Serine/Threonine-Protein Kinase Plstire

CDK6_HUMAN