Anti-ITM2B antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Q9Y287

Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.

ITM2B

Rabbit polyclonal against ITM2B

Integral Membrane Protein 2b: Golgi Apparatus Membrane
Single-Pass Type Ii Membrane Protein
Immature Bri2 (Imbri2) Is Cleaved By Furin In The Golgi Into Mbri2 And A Bri23 Peptide
Mbri2 Is Transported To The Plasma Membrane And Bri23 Peptide Is Secreted
Bri2
Membrane Form: Cell Membrane
Endosome Membrane
Mature Bri2 (Mbri2) Needs To Be Transported From The Endoplasmic Reticulum Compartment To The Cell Membrane In Order To Be Able To Inhibit App Processing
Bri23 Peptide: Secreted
Detected In The Cerebral Spinal Fluid (Csf)
Bri2c
Soluble Form: Secreted

WB 1:500-1:2000

Integral Membrane Protein 2b
Immature Bri2
Imbri2
Protein E25b
Transmembrane Protein Bri
Bri Cleaved Into-Bri2-Membrane Form
Mature Bri2
Mbri2-Bri2 Intracellular Domain
Bri2 Icd-Bri2c-Soluble Form-Bri23 Peptide
Bri2-23
Abri23
C-Terminal Peptide
P23 Peptide

ITM2B_HUMAN