Anti-A1CF antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Q9NQ94

Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Several transcript variants encoding a few different isoforms have been found for this gene.

A1CF

Rabbit polyclonal against A1CF

Nucleus
Endoplasmic Reticulum
Cytoplasm
Predominantly Nuclear Where It Localizes To Heterochromatin
Also Cytoplasmic Where It Is Found At The Outer Surface Of The Endoplasmic Reticulum
Shuttles Between The Nucleus And Cytoplasm
May Be Transported Into The Nucleus By The Nuclear Import Protein Tnpo2/Trn2 Or By Apobec1

WB 1:500-1:2000

Apobec1 Complementation Factor
Apobec1-Stimulating Protein

A1CF_HUMAN