Item no. |
STJ114982-50 |
Manufacturer |
St John's Laboratory
|
Amount |
50ul |
Category |
|
Type |
Antibody Polyclonal |
Applications |
WB |
Specific against |
Human, Mouse |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Anti-Neutrophil Elastase antibody</br>Anti-Bone Marrow Serine Protease antibody</br>Anti-Elastase-2 antibody</br>Anti-Human Leukocyte Elastase antibody</br>Anti-Hle antibody</br>Anti-Medullasin antibody</br>Anti-Pmn Elastase antibody</br>Anti-ELANE ELA2 a |
Similar products |
Anti-Neutrophil Elastase antibodyAnti-Bone Marrow Serine Protease antibodyAnti-Elastase-2 antibodyAnti-Human Leukocyte Elastase antibodyAnti-Hle antibodyAnti-Medullasin antibodyAnti-Pmn Elastase antibodyAnti-ELANE ELA2 a |
Available |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification |
Affinity purification |
Uniprot ID |
P08246 |
Storage |
Store at-20° C and avoid freeze-thaw cycles. |
Description |
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19. |
Gene ID |
|
Gene symbol |
|
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 30-267 of human ELANE (NP_001963. 1). |
Short Description |
Rabbit polyclonal against ELANE |
Tissue specificity |
Bone marrow cells. Neutrophil. |
Cellular localization |
Cytoplasmic VesiclePhagosomeLocalized In Phagolysosomes Following Ingestion Of EColi By Neutrophils |
Molecular weight |
Calculated: 28kDa. Observed: 29kDa |
Dilution range |
WB 1:500-1:2000 |
Alternative names |
Anti-Neutrophil Elastase antibodyAnti-Bone Marrow Serine Protease antibodyAnti-Elastase-2 antibodyAnti-Human Leukocyte Elastase antibodyAnti-Hle antibodyAnti-Medullasin antibodyAnti-Pmn Elastase antibodyAnti-ELANE ELA2 antibody |
Protein name |
Neutrophil ElastaseBone Marrow Serine ProteaseElastase-2Human Leukocyte ElastaseHleMedullasinPmn Elastase |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
|
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.