Item no. |
STJ114908-100 |
Manufacturer |
St John's Laboratory
|
Amount |
100ul |
Category |
|
Type |
Antibody Polyclonal |
Applications |
WB |
Specific against |
Human, Mouse |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Anti-Lymphoid Enhancer-Binding Factor 1 antibody</br>Anti-Lef-1 antibody</br>Anti-T Cell-Specific Transcription Factor 1-Alpha antibody</br>Anti-Tcf1-Alpha antibody</br>Anti-LEF1 antibody |
Similar products |
Anti-Lymphoid Enhancer-Binding Factor 1 antibodyAnti-Lef-1 antibodyAnti-T Cell-Specific Transcription Factor 1-Alpha antibodyAnti-Tcf1-Alpha antibodyAnti-LEF1 antibody |
Available |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification |
Affinity purification |
Uniprot ID |
Q9UJU2 |
Storage |
Store at-20° C and avoid freeze-thaw cycles. |
Description |
This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. |
Gene ID |
|
Gene symbol |
|
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 100-399 of human LEF1 (NP_057353. 1). |
Short Description |
Rabbit polyclonal against LEF1 |
Tissue specificity |
Detected in thymus. Not detected in normal colon, but highly expressed in colon cancer biopsies and colon cancer cell lines. Expressed in several pancreatic tumors and weakly expressed in normal pancreatic tissue. Isoforms 1 and 5 are detected in several pancreatic cell lines. |
Cellular localization |
NucleusFound In Nuclear Bodies Upon Piasg Binding |
Molecular weight |
Calculated: 23kDa/31kDa/34kDa/35kDa/41kDa/42kDa/44kDa. Observed: 40kDa |
Dilution range |
WB 1:500-1:2000 |
Alternative names |
Anti-Lymphoid Enhancer-Binding Factor 1 antibodyAnti-Lef-1 antibodyAnti-T Cell-Specific Transcription Factor 1-Alpha antibodyAnti-Tcf1-Alpha antibodyAnti-LEF1 antibody |
Protein name |
Lymphoid Enhancer-Binding Factor 1Lef-1T Cell-Specific Transcription Factor 1-AlphaTcf1-Alpha |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
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Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.