Anti-MICA antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Q29983

This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants.

MICA

Rabbit polyclonal against MICA

Cell Membrane
Single-Pass Type I Membrane Protein
Cytoplasm
Expressed On The Cell Surface In Gastric Epithelium
Endothelial Cells And Fibroblasts And In The Cytoplasm In Keratinocytes And Monocytes
Infection With Human Adenovirus 5 Suppresses Cell Surface Expression Due To The Adenoviral E3-19k Protein Which Causes Retention In The Endoplasmic Reticulum

WB 1:500-1:2000 IHC 1:50-1:200

Mhc Class I Polypeptide-Related Sequence A
Mic-A

MICA_HUMAN