Anti-ASXL1 antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Q8IXJ9

This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants.

ASXL1

Rabbit polyclonal against ASXL1

Nucleus

WB 1:500-1:2000

Polycomb Group Protein Asxl1
Additional Sex Combs-Like Protein 1

ASXL1_HUMAN