Item no. |
STJ99074-200 |
Manufacturer |
St John's Laboratory
|
Amount |
200ul |
Category |
|
Type |
Antibody Monoclonal |
Applications |
WB, IP |
Clone |
3B11-G8-B1 |
Specific against |
Human, Mouse, Rat |
Host |
Mouse |
Isotype |
IgG1 |
ECLASS 10.1 |
42030590 |
ECLASS 11.0 |
42030590 |
UNSPSC |
12352203 |
Alias |
RAC-alpha serine/threonine-protein kinase </br> Protein kinase B </br> PKB </br> Protein kinase B alpha </br> PKB alpha </br> Proto-oncogene c-Akt </br> RAC-PK-alpha |
Similar products |
RAC-alpha serine/threonine-protein kinase Protein kinase B PKB Protein kinase B alpha PKB alpha Proto-oncogene c-Akt RAC-PK-alpha |
Available |
|
Clonality |
Monoclonal |
Conjugation |
Unconjugated |
Formulation |
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Uniprot ID |
P31749 |
Storage |
Store at-20° C, and avoid repeat freeze-thaw cycles. |
Concentration |
1 mg/ml |
Description |
Mouse monoclonal to Akt (pan). |
Gene ID |
|
Gene symbol |
|
Immunogen |
Purified recombinant human AKT1 protein fragments expressed in E.coli. |
Short Description |
Mouse monoclonal against Akt (pan) |
Tissue specificity |
Expressed in prostate cancer and levels increase from the normal to the malignant state (at protein level). Expressed in all human cell types so far analyzed. The Tyr-176 phosphorylated form shows a significant increase in expression in breast cancers during the progressive stages i.e. normal to hyperplasia (ADH), ductal carcinoma in situ (DCIS), invasive ductal carcinoma (IDC) and lymph node metastatic (LNMM) stages. |
Cellular localization |
Cytoplasm. Nucleus. Cell membrane. Nucleus after activation by integrin-linked protein kinase 1 (ILK1). Nuclear translocation is enhanced by interaction with TCL1A. Phosphorylation on Tyr-176 by TNK2 results in its localization to the cell membrane where it is targeted for further phosphorylations on Thr-308 and Ser-473 leading to its activation and the activated form translocates to the nucleus. Colocalizes with WDFY2 in intracellular vesicles. |
Molecular weight |
60kDa |
Dilution range |
WB 1:1000 |
Alternative names |
RAC-alpha serine/threonine-protein kinase Protein kinase B PKB Protein kinase B alpha PKB alpha Proto-oncogene c-Akt RAC-PK-alpha |
Protein name |
RAC-alpha serine/threonine-protein kinase Protein kinase B PKB Protein kinase B alpha PKB alpha Proto-oncogene c-Akt RAC-PK-alpha |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
|
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.