Item no. |
STJ93687-200 |
Manufacturer |
St John's Laboratory
|
Amount |
200ul |
Category |
|
Type |
Antibody Polyclonal |
Applications |
WB, ELISA, IHC-P |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Anti-Interleukin-1 Beta antibody</br>Anti-Il-1 Beta antibody</br>Anti-Catabolin antibody</br>Anti-IL1B IL1F2 antibody |
Similar products |
Anti-Interleukin-1 Beta antibodyAnti-Il-1 Beta antibodyAnti-Catabolin antibodyAnti-IL1B IL1F2 antibody |
Available |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Uniprot ID |
P01584 |
Storage |
Store at-20° C, and avoid repeat freeze-thaw cycles. |
Concentration |
1 mg/ml |
Description |
Rabbit polyclonal to IL-1beta. |
Gene ID |
|
Gene symbol |
|
Immunogen |
Synthesized peptide derived from human IL-1beta. |
Immunogen region |
Internal |
Short Description |
Rabbit polyclonal against IL-beta |
Tissue specificity |
Expressed in activated monocytes/macrophages (at protein level). |
Cellular localization |
CytoplasmCytosolLysosomeSecretedExtracellular ExosomeThe Precursor Is CytosolicIn Response To Inflammasome-Activating SignalsSuch As Atp For Nlrp3 Inflammasome Or Bacterial Flagellin For Nlrc4 InflammasomeCleaved And SecretedIl1b Lacks Any Known Signal Sequence And The Pathway(S) Of Its Secretion Is(Are) Not Yet Fully Understood On The Basis Of Experimental ResultsSeveral Unconventional Secretion Mechanisms Have Been Proposed1Secretion Via Secretory Lysosomes: A Fraction Of Casp1 And Il1b Precursor May Be IncorporatedBy A Yet Undefined MechanismInto Secretory Lysosomes That Undergo Ca(2+)-Dependent Exocytosis With Release Of Mature Il1b 2Secretory Autophagy: Il1b-Containing Autophagosomes May Fuse With Endosomes Or Multivesicular Bodies (Mvbs) And Then Merge With The Plasma Membrane Releasing Soluble Il1b Or Il1b-Containing Exosomes HoweverAutophagy Impacts Il1b Production At Several Levels And Its Role In Secretion Is Still Controversial3Secretion Via Exosomes: Atp-Activation Of P2rx7 Leads To The Formation Of Mvbs Containing Exosomes With Entrapped Il1bCasp1 And Other Inflammasome ComponentsThese Mvbs Undergo Exocytosis With The Release Of ExosomesThe Release Of Soluble Il1b Occurs After The Lysis Of Exosome Membranes (By Similarity)4Secretion By Microvesicle Shedding: Activation Of The Atp Receptor P2rx7 May Induce An Immediate Shedding Of Membrane-Derived Microvesicles Containing Il1b And Possibly Inflammasome ComponentsThe Cytokine Is Then Released In The Extracellular Compartment After Microvesicle Lysis 5Release By Translocation Through Permeabilized Plasma MembraneThis May Occur In Cells Undergoing Pyroptosis Due To Sustained Activation Of The Inflammasome (By Similarity)These Mechanisms May Not Be Not Mutually Exclusive |
Molecular weight |
31 kDa |
Dilution range |
WB 1:500-1:2000IHC 1:100-1:300ELISA 1:5000 |
Alternative names |
Anti-Interleukin-1 Beta antibodyAnti-Il-1 Beta antibodyAnti-Catabolin antibodyAnti-IL1B IL1F2 antibody |
Protein name |
Interleukin-1 BetaIl-1 BetaCatabolin |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
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Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.