Anti-Cyclin B1 antibody

Unconjugated

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Store at-20° C, and avoid repeat freeze-thaw cycles.

Cyclin B1 is a protein encoded by the CCNB1 gene which is approximately 48, 3 kDa. Cyclin B1 is localised to the cytoplasm and nucleus. It is involved in CDK-mediated phosphorylation and removal of Cdc6, regulation of PLK1 activity at G2/M transition and DNA damage response. This protein falls under the highly conserved cyclin family. It is a regulatory protein involved in mitosis. It forms a complex with p34(cdc2) to form the maturation-promoting factor. Cyclin B1 is expressed in the nervous system, skin, intestine, liver and lung. Mutations in the CCNB1 gene may result in thyroid lymphoma and cervical cancer. STJ92534 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Cyclin B1 protein.

CCNB1

60-140 aa

Cytoplasm
Nucleus
Cytoskeleton
Microtubule Organizing Center
Centrosome

WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:20000

G2/Mitotic-Specific Cyclin-B1

CCNB1_HUMAN