Anti-Cbl antibody

Unconjugated

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Store at-20° C, and avoid repeat freeze-thaw cycles.

Cbl is a protein encoded by the CBL gene which is approximately 99, 6 kDa. Cbl is localised to the cytoplasm and cell membrane. It is involved in negative regulation of FGFR1 signalling, signalling by EGFR in cancer and the T cell receptor signalling pathway. It is an adapter protein that functions as a negative regulator of many signalling pathways that are triggered by activation of cell surface receptors. It accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Cbl is expressed in blood and cells of the nervous system. Mutations in the CBL gene may result in a Noonan syndrome-like disorder. STJ92057 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Cbl protein.

CBL

610-690 aa

Cytoplasm
Cell Membrane
Cell Projection
Cilium
Golgi Apparatus
Colocalizes With Fgfr2 In Lipid Rafts At The Cell Membrane

WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:5000

E3 Ubiquitin-Protein Ligase Cbl
Casitas B-Lineage Lymphoma Proto-Oncogene
Proto-Oncogene C-Cbl
Ring Finger Protein 55
Ring-Type E3 Ubiquitin Transferase Cbl
Signal Transduction Protein Cbl

CBL_HUMAN