Item no. |
STJ90336-100 |
Manufacturer |
St John's Laboratory
|
Amount |
100ul |
Category |
|
Type |
Antibody Polyclonal |
Applications |
WB, IF, ELISA, IHC-P |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Anti-Serine/Threonine-Protein Kinase Mtor antibody</br>Anti-Fk506-Binding Protein 12-Rapamycin Complex-Associated Protein 1 antibody</br>Anti-Fkbp12-Rapamycin Complex-Associated Protein antibody</br>Anti-Mammalian Target Of Rapamycin antibody</br>Anti-Mto |
Similar products |
Anti-Serine/Threonine-Protein Kinase Mtor antibodyAnti-Fk506-Binding Protein 12-Rapamycin Complex-Associated Protein 1 antibodyAnti-Fkbp12-Rapamycin Complex-Associated Protein antibodyAnti-Mammalian Target Of Rapamycin antibodyAnti-Mto |
Available |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Uniprot ID |
P42345 |
Storage |
Store at-20° C, and avoid repeat freeze-thaw cycles. |
Concentration |
1 mg/ml |
Description |
mTOR is a protein encoded by the MTOR gene which is approximately 288, 9 kDa. mTOR is localised to the endoplasmic reticulum membrane and mitochondrion outer membrane. It is involved in RET signalling, regulation of lipid metabolism, mTOR signalling and glioma. This protein falls under the phosphatidylinositol kinase family. It is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. mTOR is expressed in numerous tissues, with highest levels expressed in the testis. Mutations in the MTOR gene may result in Smith-Kingsmore syndrome. STJ90336 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous mTOR protein which only binds about S2448 when S2448 is phosphorylated. |
Gene ID |
|
Gene symbol |
|
Immunogen |
Synthesized peptide derived from human mTOR around the phosphorylation site of S2448. |
Immunogen region |
2390-2470 aa |
Short Description |
Rabbit polyclonal against Phospho-mTOR (S2448) |
Tissue specificity |
Expressed in numerous tissues, with highest levels in testis. |
Cellular localization |
Endoplasmic Reticulum MembranePeripheral Membrane ProteinCytoplasmic SideGolgi Apparatus MembraneMitochondrion Outer MembraneLysosomeCytoplasmNucleusPml BodyMicrosome MembraneLysosome MembraneShuttles Between Cytoplasm And NucleusAccumulates In The Nucleus In Response To Hypoxia (By Similarity)Targeting To Lysosomes Depends On Amino Acid Availability And Rraga And Rragb Lysosome Targeting Also Depends On Interaction With Meak7Translocates To The Lysosome Membrane In The Presence Of Tm4sf5 |
Molecular weight |
288 kDa |
Dilution range |
WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:40000 |
Alternative names |
Anti-Serine/Threonine-Protein Kinase Mtor antibodyAnti-Fk506-Binding Protein 12-Rapamycin Complex-Associated Protein 1 antibodyAnti-Fkbp12-Rapamycin Complex-Associated Protein antibodyAnti-Mammalian Target Of Rapamycin antibodyAnti-Mtor antibodyAnti-Mechanistic Target Of Rapamycin antibodyAnti-Rapamycin And Fkbp12 Target 1 antibodyAnti-Rapamycin Target Protein 1 antibodyAnti-MTOR FRAP FRAP1 FRAP2 RAFT1 RAPT1 antibody |
Protein name |
Serine/Threonine-Protein Kinase MtorFk506-Binding Protein 12-Rapamycin Complex-Associated Protein 1Fkbp12-Rapamycin Complex-Associated ProteinMammalian Target Of RapamycinMtorMechanistic Target Of RapamycinRapamycin And Fkbp12 Target 1Rapamycin Target Protein 1 |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
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Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.