Item no. |
STJ29218-50 |
Manufacturer |
St John's Laboratory
|
Amount |
50ul |
Category |
|
Type |
Antibody Polyclonal |
Applications |
WB, IF, IHC |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Anti-Pre-Mrna 3'-End-Processing Factor Fip1 antibody</br>Anti-Hfip1 antibody</br>Anti-Fip1-Like 1 Protein antibody</br>Anti-Factor Interacting With Pap antibody</br>Anti-Rearranged In Hypereosinophilia antibody</br>Anti-FIP1L1 FIP1 RHE antibody |
Similar products |
Anti-Pre-Mrna 3'-End-Processing Factor Fip1 antibodyAnti-Hfip1 antibodyAnti-Fip1-Like 1 Protein antibodyAnti-Factor Interacting With Pap antibodyAnti-Rearranged In Hypereosinophilia antibodyAnti-FIP1L1 FIP1 RHE antibody |
Available |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification |
Affinity purification |
Uniprot ID |
Q6UN15 |
Storage |
Store at-20° C and avoid freeze-thaw cycles. |
Description |
This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
Gene ID |
|
Gene symbol |
|
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human FIP1L1 (NP_001128409. 1). |
Short Description |
Rabbit polyclonal against FIP1L1 |
Cellular localization |
Nucleus |
Molecular weight |
Calculated: 40kDa/58kDa/65kDa/66kDa. Observed: 80kDa |
Dilution range |
WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:100 |
Alternative names |
Anti-Pre-Mrna 3'-End-Processing Factor Fip1 antibodyAnti-Hfip1 antibodyAnti-Fip1-Like 1 Protein antibodyAnti-Factor Interacting With Pap antibodyAnti-Rearranged In Hypereosinophilia antibodyAnti-FIP1L1 FIP1 RHE antibody |
Protein name |
Pre-Mrna 3'-End-Processing Factor Fip1Hfip1Fip1-Like 1 ProteinFactor Interacting With PapRearranged In Hypereosinophilia |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
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Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.