Anti-GALE antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Q14376

This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild ('peripheral' form) to severe ('generalized' form). Multiple alternatively spliced transcripts encoding the same protein have been identified.

GALE

Rabbit polyclonal against GALE

WB 1:500-1:2000 IHC 1:50-1:200 IF 1:10-1:100

Udp-Glucose 4-Epimerase
Galactowaldenase
Udp-N-Acetylgalactosamine 4-Epimerase
Udp-Galnac 4-Epimerase
Udp-N-Acetylglucosamine 4-Epimerase
Udp-Glcnac 4-Epimerase
Udp-Galactose 4-Epimerase

GALE_HUMAN