Item no. |
STJ27534-50 |
Manufacturer |
St John's Laboratory
|
Amount |
50ul |
Category |
|
Type |
Antibody Polyclonal |
Applications |
WB, IHC |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Anti-Receptor Tyrosine-Protein Kinase Erbb-3 antibody</br>Anti-Proto-Oncogene-Like Protein C-Erbb-3 antibody</br>Anti-Tyrosine Kinase-Type Cell Surface Receptor Her3 antibody</br>Anti-ERBB3 HER3 antibody |
Similar products |
Anti-Receptor Tyrosine-Protein Kinase Erbb-3 antibodyAnti-Proto-Oncogene-Like Protein C-Erbb-3 antibodyAnti-Tyrosine Kinase-Type Cell Surface Receptor Her3 antibodyAnti-ERBB3 HER3 antibody |
Available |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification |
Affinity purification |
Uniprot ID |
P21860 |
Storage |
Store at-20° C and avoid freeze-thaw cycles. |
Description |
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. |
Gene ID |
|
Gene symbol |
|
Immunogen |
A synthetic peptide of human ERBB3 |
Short Description |
Rabbit polyclonal against ERBB3 |
Tissue specificity |
Epithelial tissues and brain. |
Cellular localization |
Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Secreted |
Molecular weight |
Calculated: 20kDa/36kDa/77kDa/141kDa/148kDa. Observed: 180kDa |
Dilution range |
WB 1:500-1:1000 IHC 1:50-1:100 |
Alternative names |
Anti-Receptor Tyrosine-Protein Kinase Erbb-3 antibodyAnti-Proto-Oncogene-Like Protein C-Erbb-3 antibodyAnti-Tyrosine Kinase-Type Cell Surface Receptor Her3 antibodyAnti-ERBB3 HER3 antibody |
Protein name |
Receptor Tyrosine-Protein Kinase Erbb-3Proto-Oncogene-Like Protein C-Erbb-3Tyrosine Kinase-Type Cell Surface Receptor Her3 |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
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Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.