Anti-STAT3 antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

P40763

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo-or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

STAT3

Rabbit polyclonal against STAT3

Cytoplasm
Nucleus
Shuttles Between The Nucleus And The Cytoplasm
Translocated Into The Nucleus Upon Tyrosine Phosphorylation And Dimerization
In Response To Signaling By Activated Fgfr1
Fgfr2
Fgfr3 Or Fgfr4
Constitutive Nuclear Presence Is Independent Of Tyrosine Phosphorylation
Predominantly Present In The Cytoplasm Without Stimuli
Upon Leukemia Inhibitory Factor (Lif) Stimulation
Accumulates In The Nucleus
The Complex Composed Of Bart And Arl2 Plays An Important Role In The Nuclear Translocation And Retention Of Stat3
Identified In A Complex With Lyn And Pag1

IHC 1:50-1:100

Signal Transducer And Activator Of Transcription 3
Acute-Phase Response Factor

STAT3_HUMAN