Item no. |
STJ24811-50 |
Manufacturer |
St John's Laboratory
|
Amount |
50ul |
Category |
|
Type |
Antibody Polyclonal |
Applications |
WB, IHC |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Anti-Nuclear Receptor Subfamily 1 Group I Member 2 antibody</br>Anti-Orphan Nuclear Receptor Par1 antibody</br>Anti-Orphan Nuclear Receptor Pxr antibody</br>Anti-Pregnane X Receptor antibody</br>Anti-Steroid And Xenobiotic Receptor antibody</br>Anti-Sxr a |
Similar products |
Anti-Nuclear Receptor Subfamily 1 Group I Member 2 antibodyAnti-Orphan Nuclear Receptor Par1 antibodyAnti-Orphan Nuclear Receptor Pxr antibodyAnti-Pregnane X Receptor antibodyAnti-Steroid And Xenobiotic Receptor antibodyAnti-Sxr a |
Available |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification |
Affinity purification |
Uniprot ID |
O75469 |
Storage |
Store at-20° C and avoid freeze-thaw cycles. |
Description |
This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. |
Gene ID |
|
Gene symbol |
|
Immunogen |
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human NR1I2 (NP_071285. 1). |
Short Description |
Rabbit polyclonal against NR1I2 |
Tissue specificity |
Expressed in liver, colon and small intestine. |
Cellular localization |
Nucleus |
Molecular weight |
Calculated: 39kDa/43kDa/45kDa/48kDa/49kDa/52kDa/53kDa. Observed: 49kDa |
Dilution range |
WB 1:500-1:2000 IHC 1:50-1:200 |
Alternative names |
Anti-Nuclear Receptor Subfamily 1 Group I Member 2 antibodyAnti-Orphan Nuclear Receptor Par1 antibodyAnti-Orphan Nuclear Receptor Pxr antibodyAnti-Pregnane X Receptor antibodyAnti-Steroid And Xenobiotic Receptor antibodyAnti-Sxr antibodyAnti-NR1I2 PXR antibody |
Protein name |
Nuclear Receptor Subfamily 1 Group I Member 2Orphan Nuclear Receptor Par1Orphan Nuclear Receptor PxrPregnane X ReceptorSteroid And Xenobiotic ReceptorSxr |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
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Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.