Anti-CEACAM1 antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

P13688

This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1. 2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined.

CEACAM1

Rabbit polyclonal against CEACAM1

Isoform 1: Cell Membrane
Single-Pass Type I Membrane Protein
Lateral Cell Membrane
Apical Cell Membrane
Basal Cell Membrane
Cell Junction
Adherens Junction
Canalicular Domain Of Hepatocyte Plasma Membranes
Found As A Mixture Of Monomer
Dimer And Oligomer In The Plasma Membrane
Occurs Predominantly As Cis-Dimers And/Or Small Cis-Oligomers In The Cell Junction Regions
Found As Dimer In The Solution
Predominantly Localized To The Lateral Cell Membranes
Isoform 2: Secreted
Isoform 3: Secreted
Isoform 4: Secreted
Isoform 5: Cell Membrane
Isoform 6: Cell Membrane
Isoform 7: Cell Membrane
Isoform 8: Cell Membrane
Cytoplasmic Vesicle
Secretory Vesicle Membrane
Co-Localizes With Anxa2 In Secretory Vesicles And With S100a10/P11 At The Plasma Membrane
Cell Projection
Microvillus Membrane
Localized To The Apical Glycocalyx Surface
Colocalizes With Ceacam20 At The Apical Brush Border Of Intestinal Cells

WB 1:500-1:2000

Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1
Biliary Glycoprotein 1
Bgp-1
Cd Antigen Cd66a

CEAM1_HUMAN