Item no. |
STJ22718-50 |
Manufacturer |
St John's Laboratory
|
Amount |
50ul |
Category |
|
Type |
Antibody Polyclonal |
Applications |
WB, IF, IHC |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Anti-Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 2 antibody</br>Anti-Serca2 antibody</br>Anti-Sr Ca(2+-Atpase 2 antibody</br>Anti-Calcium Pump 2 antibody</br>Anti-Calcium-Transporting Atpase Sarcoplasmic Reticulum Type-Slow Twitch Skeletal Muscle Is |
Similar products |
Anti-Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 2 antibodyAnti-Serca2 antibodyAnti-Sr Ca(2+-Atpase 2 antibodyAnti-Calcium Pump 2 antibodyAnti-Calcium-Transporting Atpase Sarcoplasmic Reticulum Type-Slow Twitch Skeletal Muscle Is |
Available |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification |
Affinity purification |
Uniprot ID |
P16615 |
Storage |
Store at-20° C and avoid freeze-thaw cycles. |
Description |
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms. |
Gene ID |
|
Gene symbol |
|
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 111-253 of human ATP2A2 (NP_733765. 1). |
Short Description |
Rabbit polyclonal against ATP2A2 |
Tissue specificity |
Isoform 1 is widely expressed in smooth muscle and nonmuscle tissues such as in adult skin epidermis, with highest expression in liver, pancreas and lung, and intermediate expression in brain, kidney and placenta. Also expressed at lower levels in heart and skeletal muscle. Isoforms 2 and 3 are highly expressed in the heart and slow twitch skeletal muscle. Expression of isoform 3 is predominantly restricted to cardiomyocytes and in close proximity to the sarcolemma. Both isoforms are mildly expressed in lung, kidney, liver, pancreas and placenta. Expression of isoform 3 is amplified during monocytic differentiation and also observed in the fetal heart. |
Cellular localization |
Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinSarcoplasmic Reticulum Membrane |
Molecular weight |
Calculated: 109kDa/111kDa/114kDa. Observed: 115kDa |
Dilution range |
WB 1:500-1:2000 IHC 1:50-1:200 IF 1:10-1:100 |
Alternative names |
Anti-Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 2 antibodyAnti-Serca2 antibodyAnti-Sr Ca(2+-Atpase 2 antibodyAnti-Calcium Pump 2 antibodyAnti-Calcium-Transporting Atpase Sarcoplasmic Reticulum Type-Slow Twitch Skeletal Muscle Isoform antibodyAnti-Endoplasmic Reticulum Class 1/2 Ca(2+ Atpase antibodyAnti-ATP2A2 ATP2B antibody |
Protein name |
Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 2Serca2Sr Ca(2+-Atpase 2Calcium Pump 2Calcium-Transporting Atpase Sarcoplasmic Reticulum Type-Slow Twitch Skeletal Muscle IsoformEndoplasmic Reticulum Class 1/2 Ca(2+ Atpase |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
|
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.