Anti-Phospho-ERBB4-(Y1284) antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Q15303

This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

ERBB4

Rabbit polyclonal against Phospho-ERBB4-(Y1284)

Cell Membrane
Single-Pass Type I Membrane Protein
In Response To Nrg1 Treatment
The Activated Receptor Is Internalized
Erbb4 Intracellular Domain: Nucleus
Mitochondrion
Following Proteolytical Processing E4icd (E4icd1 Or E4icd2 Generated From The Respective Isoforms) Is Translocated To The Nucleus
Significantly More E4icd2 Than E4icd1 Is Found In The Nucleus
E4icd2 Colocalizes With Yap1 In The Nucleus

WB 1:500-1:2000

Receptor Tyrosine-Protein Kinase Erbb-4
Proto-Oncogene-Like Protein C-Erbb-4
Tyrosine Kinase-Type Cell Surface Receptor Her4
P180erbb4 Cleaved Into-Erbb4 Intracellular Domain
4icd
E4icd
S80her4

ERBB4_HUMAN