Item no. |
STJ117893-100 |
Manufacturer |
St John's Laboratory
|
Amount |
100ul |
Category |
|
Type |
Antibody Polyclonal |
Applications |
WB |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Anti-Catenin Beta-1 antibody</br>Anti-Beta-Catenin antibody</br>Anti-CTNNB1 CTNNB OK/SW-cl.35 PRO2286 antibody |
Similar products |
Anti-Catenin Beta-1 antibodyAnti-Beta-Catenin antibodyAnti-CTNNB1 CTNNB OK/SW-cl.35 PRO2286 antibody |
Available |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification |
Affinity purification |
Uniprot ID |
P35222 |
Storage |
Store at-20° C and avoid freeze-thaw cycles. |
Description |
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. |
Gene ID |
|
Gene symbol |
|
Immunogen |
A synthetic phosphorylated peptide around S675 of human CTNNB1 (NP_001091679. 1). |
Short Description |
Rabbit polyclonal against Phospho-CTNNB1-(S675) |
Tissue specificity |
Expressed in several hair follicle cell types: basal and peripheral matrix cells, and cells of the outer and inner root sheaths. Expressed in colon. Present in cortical neurons (at protein level). Expressed in breast cancer tissues (at protein level). |
Cellular localization |
CytoplasmNucleusCytoskeletonCell JunctionAdherens JunctionCell MembraneMicrotubule Organizing CenterCentrosomeSpindle PoleSynapseCilium Basal BodyColocalized With Rapgef2 And Tjp1 At Cell-Cell ContactsCytoplasmic When It Is Unstabilized (High Level Of Phosphorylation) Or Bound To Cdh1Translocates To The Nucleus When It Is Stabilized (Low Level Of Phosphorylation)Interaction With Glis2 And Muc1 Promotes Nuclear TranslocationInteraction With Emd Inhibits Nuclear LocalizationThe Majority Of Beta-Catenin Is Localized To The Cell MembraneIn InterphaseColocalizes With Crocc Between Cep250 Puncta At The Proximal End Of CentriolesAnd This Localization Is Dependent On Crocc And Cep250In MitosisWhen Nek2 Activity IncreasesIt Localizes To Centrosomes At Spindle Poles Independent Of CroccColocalizes With Cdk5 In The Cell-Cell Contacts And Plasma Membrane Of Undifferentiated And Differentiated Neuroblastoma CellsInteraction With Fam53b Promotes Translocation To The Nucleus |
Molecular weight |
Calculated: 9kDa/85kDa. Observed: 100kDa |
Dilution range |
WB 1:500-1:2000 |
Alternative names |
Anti-Catenin Beta-1 antibodyAnti-Beta-Catenin antibodyAnti-CTNNB1 CTNNB OK/SW-cl.35 PRO2286 antibody |
Protein name |
Catenin Beta-1Beta-Catenin |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
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Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.