Anti-DLAT antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

P10515

This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.

DLAT

Rabbit polyclonal against DLAT

Calculated: 68kDa. Observed: 69kDa

Anti-Dihydrolipoyllysine-Residue Acetyltransferase Component Of Pyruvate Dehydrogenase Complex-Mitochondrial antibody
Anti-70 Kda Mitochondrial Autoantigen Of Primary Biliary Cirrhosis antibody
Anti-Pbc antibody
Anti-Dihydrolipoamide Acetyltransferase Component Of Pyruvate Dehydrogenase Complex antibody
Anti-M2 Antigen Complex 70 Kda Subunit antibody
Anti-Pyruvate Dehydrogenase Complex Component E2 antibody
Anti-Pdc-E2 antibody
Anti-Pdce2 antibody
Anti-DLAT DLTA antibody

FOR RESEARCH USE ONLY (RUO).