Anti-SKP2 antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Q13309

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms.

SKP2

Rabbit polyclonal against SKP2

Calculated: 23kDa/46kDa/47kDa. Observed: 45kDa

Anti-S-Phase Kinase-Associated Protein 2 antibody
Anti-Cyclin-A/Cdk2-Associated Protein P45 antibody
Anti-F-Box Protein Skp2 antibody
Anti-F-Box/Lrr-Repeat Protein 1 antibody
Anti-P45skp2 antibody
Anti-SKP2 FBXL1 antibody

FOR RESEARCH USE ONLY (RUO).