Item no. |
STJ112892-50 |
Manufacturer |
St John's Laboratory
|
Amount |
50ul |
Category |
|
Type |
Antibody Polyclonal |
Applications |
WB, IHC |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Anti-Amyloid-Beta Precursor Protein antibody</br>Anti-App antibody</br>Anti-Abpp antibody</br>Anti-Appi antibody</br>Anti-Alzheimer Disease Amyloid Protein antibody</br>Anti-Amyloid Precursor Protein antibody</br>Anti-Amyloid-Beta A4 Protein antibody</br> |
Similar products |
Anti-Amyloid-Beta Precursor Protein antibodyAnti-App antibodyAnti-Abpp antibodyAnti-Appi antibodyAnti-Alzheimer Disease Amyloid Protein antibodyAnti-Amyloid Precursor Protein antibodyAnti-Amyloid-Beta A4 Protein antibody |
Available |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification |
Affinity purification |
Uniprot ID |
P05067 |
Storage |
Store at-20° C and avoid freeze-thaw cycles. |
Description |
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. |
Gene ID |
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Gene symbol |
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Immunogen |
A synthetic peptide of human APP |
Short Description |
Rabbit polyclonal against APP |
Tissue specificity |
Expressed in the brain and in cerebrospinal fluid (at protein level). Expressed in all fetal tissues examined with highest levels in brain, kidney, heart and spleen. Weak expression in liver. In adult brain, highest expression found in the frontal lobe of the cortex and in the anterior perisylvian cortex-opercular gyri. Moderate expression in the cerebellar cortex, the posterior perisylvian cortex-opercular gyri and the temporal associated cortex. Weak expression found in the striate, extra-striate and motor cortices. Expressed in cerebrospinal fluid, and plasma. Isoform APP695 is the predominant form in neuronal tissue, isoform APP751 and isoform APP770 are widely expressed in non-neuronal cells. Isoform APP751 is the most abundant form in T-lymphocytes. Appican is expressed in astrocytes. |
Cellular localization |
Cell MembraneSingle-Pass Type I Membrane ProteinMembranePerikaryonCell ProjectionGrowth ConeClathrin-Coated PitEarly EndosomeCytoplasmic VesicleCell Surface Protein That Rapidly Becomes Internalized Via Clathrin-Coated PitsOnly A Minor Proportion Is Present At The Cell MembraneMost Of The Protein Is Present In Intracellular VesiclesDuring MaturationThe Immature App (N-Glycosylated In The Endoplasmic Reticulum) Moves To The Golgi Complex Where Complete Maturation Occurs (O-Glycosylated And Sulfated)After Alpha-Secretase CleavageSoluble App Is Released Into The Extracellular Space And The C-Terminal Is Internalized To Endosomes And LysosomesSome App Accumulates In Secretory Transport Vesicles Leaving The Late Golgi Compartment And Returns To The Cell SurfaceApp Sorts To The Basolateral Surface In Epithelial CellsDuring Neuronal DifferentiationThe Thr-743 Phosphorylated Form Is Located Mainly In Growth ConesModerately In Neurites And Sparingly In The Cell BodyCasein Kinase Phosphorylation Can Occur Either At The Cell Surface Or Within A Post-Golgi CompartmentAssociates With Gpc1 In Perinuclear CompartmentsColocalizes With Sorl1 In A Vesicular Pattern In Cytoplasm And Perinuclear RegionsSoluble App-Beta: SecretedAmyloid-Beta Protein 42: Cell SurfaceAssociates With Fpr2 At The Cell Surface And The Complex Is Then Rapidly InternalizedGamma-Secretase C-Terminal Fragment 59: NucleusCytoplasmLocated To Both The Cytoplasm And Nuclei Of NeuronsIt Can Be Translocated To The Nucleus Through Association With Apbb1 (Fe65)In Dopaminergic NeuronsThe Phosphorylated Thr-743 Form Is Localized To The Nucleus |
Molecular weight |
Calculated: 34kDa/72-86kDa. Observed: 110kDa |
Dilution range |
WB 1:500-1:2000 IHC 1:50-1:100 |
Alternative names |
Anti-Amyloid-Beta Precursor Protein antibodyAnti-App antibodyAnti-Abpp antibodyAnti-Appi antibodyAnti-Alzheimer Disease Amyloid Protein antibodyAnti-Amyloid Precursor Protein antibodyAnti-Amyloid-Beta A4 Protein antibodyAnti-Cerebral Vascular Amyloid Peptide antibodyAnti-Cvap antibodyAnti-Prea4 antibodyAnti-Protease Nexin-Ii antibodyAnti-Pn-Ii Cleaved Into-N-App-Soluble App-Alpha antibodyAnti-S-App-Alpha-Soluble App-Beta antibodyAnti-S-App-Beta-C99 antibodyAnti-Beta-Secretase C-Terminal Fragment antibodyAnti-Beta-Ctf-Amyloid-Beta Protein 42 antibodyAnti-Abeta42 antibodyAnti-Beta-App42-Amyloid-Beta Protein 40 antibodyAnti-Abeta40 antibodyAnti-Beta-App40-C83 antibodyAnti-Alpha-Secretase C-Terminal Fragment antibodyAnti-Alpha-Ctf-P3(42-P3(40-C80-Gamma-Secretase C-Terminal Fragment 59 antibodyAnti-Amyloid Intracellular Domain 59 antibodyAnti-Aicd-59 antibodyAnti-Aid(59 antibodyAnti-Gamma-Ctf(59-Gamma-Secretase C-Terminal Fragment 57 antibodyAnti-Amyloid Intracellular Domain 57 antibodyAnti-Aicd-57 antibodyAnti-Aid(57 antibodyAnti-Gamma-Ctf(57-Gamma-Secretase C-Terminal Fragment 50 antibodyAnti-Amyloid Intracellular Domain 50 antibodyAnti-Aicd-50 antibodyAnti-Aid(50 antibodyAnti-Gamma-Ctf(50-C31 antibodyAnti-APP A4 AD1 antibody |
Protein name |
Amyloid-Beta Precursor ProteinAppAbppAppiAlzheimer Disease Amyloid ProteinAmyloid Precursor ProteinAmyloid-Beta A4 ProteinCerebral Vascular Amyloid PeptideCvapPrea4Protease Nexin-IiPn-Ii Cleaved Into-N-App-Soluble App-AlphaS-App-Alpha-Soluble App-BetaS-App-Beta-C99Beta-Secretase C-Terminal FragmentBeta-Ctf-Amyloid-Beta Protein 42Abeta42Beta-App42-Amyloid-Beta Protein 40Abeta40Beta-App40-C83Alpha-Secretase C-Terminal FragmentAlpha-Ctf-P3(42-P3(40-C80-Gamma-Secretase C-Terminal Fragment 59Amyloid Intracellular Domain 59Aicd-59Aid(59Gamma-Ctf(59-Gamma-Secretase C-Terminal Fragment 57Amyloid Intracellular Domain 57Aicd-57Aid(57Gamma-Ctf(57-Gamma-Secretase C-Terminal Fragment 50Amyloid Intracellular Domain 50Aicd-50Aid(50Gamma-Ctf(50-C31 |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.