Item no. |
STJ112563-50 |
Manufacturer |
St John's Laboratory
|
Amount |
50ul |
Category |
|
Type |
Antibody Polyclonal |
Applications |
WB |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Anti-Leucine-Rich Repeat-Containing G-Protein Coupled Receptor 5 antibody</br>Anti-G-Protein Coupled Receptor 49 antibody</br>Anti-G-Protein Coupled Receptor 67 antibody</br>Anti-G-Protein Coupled Receptor Hg38 antibody</br>Anti-LGR5 GPR49 GPR67 antibody |
Similar products |
Anti-Leucine-Rich Repeat-Containing G-Protein Coupled Receptor 5 antibodyAnti-G-Protein Coupled Receptor 49 antibodyAnti-G-Protein Coupled Receptor 67 antibodyAnti-G-Protein Coupled Receptor Hg38 antibodyAnti-LGR5 GPR49 GPR67 antibody |
Available |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification |
Affinity purification |
Uniprot ID |
O75473 |
Storage |
Store at-20° C and avoid freeze-thaw cycles. |
Description |
The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene. |
Gene ID |
|
Gene symbol |
|
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 824-907 of human LGR5 (NP_003658. 1). |
Short Description |
Rabbit polyclonal against LGR5 |
Tissue specificity |
Expressed in skeletal muscle, placenta, spinal cord, and various region of brain. Expressed at the base of crypts in colonic and small mucosa stem cells. In premalignant cancer expression is not restricted to the cript base. Overexpressed in cancers of the ovary, colon and liver. |
Cellular localization |
Cell MembraneMulti-Pass Membrane ProteinGolgi ApparatusTrans-Golgi Network MembraneRapidly And Constitutively Internalized To The Trans-Golgi Network At Steady StateInternalization To The Trans-Golgi Network May Be The Result Of Phosphorylation At Ser-861 And Ser-864HoweverThe Phosphorylation Event Has Not Been Proven |
Molecular weight |
Calculated: 92kDa/97kDa/99kDa. Observed: 105kDa |
Dilution range |
WB 1:1000-1:2000 |
Alternative names |
Anti-Leucine-Rich Repeat-Containing G-Protein Coupled Receptor 5 antibodyAnti-G-Protein Coupled Receptor 49 antibodyAnti-G-Protein Coupled Receptor 67 antibodyAnti-G-Protein Coupled Receptor Hg38 antibodyAnti-LGR5 GPR49 GPR67 antibody |
Protein name |
Leucine-Rich Repeat-Containing G-Protein Coupled Receptor 5G-Protein Coupled Receptor 49G-Protein Coupled Receptor 67G-Protein Coupled Receptor Hg38 |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
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Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.