Anti-CKAP5 antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Q14008

This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified.

CKAP5

Rabbit polyclonal against CKAP5

Cytoplasm
Cytoskeleton
Microtubule Organizing Center
Centrosome
Spindle Pole
Spindle
Chromosome
Centromere
Kinetochore
Detected On Centrosomes And Kinetochores During Interphase And Mitosis Independently From Tacc3 And Clathrin
Located To Spindle Poles And Microtubules During Mitosis
In Complex With Tacc3 Localized To Microtubule Plus-Ends In Mitosis And Interphase
In Complex With Tacc3 And Clathrin Localized To Inter-Microtubule Bridges In Mitotic Spindles
Accumulation Sites At Microtubule Plus Ends Protruded Approximately 100 Nm From Mapre1/Eb1 Sites In Interphase Cells

WB 1:500-1:2000

Cytoskeleton-Associated Protein 5
Colonic And Hepatic Tumor Overexpressed Gene Protein
Ch-Tog

CKAP5_HUMAN