Item no. |
STJ111274-50 |
Manufacturer |
St John's Laboratory
|
Amount |
50ul |
Category |
|
Type |
Antibody Polyclonal |
Applications |
WB |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Anti-Cytoskeleton-Associated Protein 5 antibody</br>Anti-Colonic And Hepatic Tumor Overexpressed Gene Protein antibody</br>Anti-Ch-Tog antibody</br>Anti-CKAP5 KIAA0097 antibody |
Similar products |
Anti-Cytoskeleton-Associated Protein 5 antibodyAnti-Colonic And Hepatic Tumor Overexpressed Gene Protein antibodyAnti-Ch-Tog antibodyAnti-CKAP5 KIAA0097 antibody |
Available |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification |
Affinity purification |
Uniprot ID |
Q14008 |
Storage |
Store at-20° C and avoid freeze-thaw cycles. |
Description |
This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified. |
Gene ID |
|
Gene symbol |
|
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 1763-2032 of human CKAP5 (NP_001008938. 1). |
Short Description |
Rabbit polyclonal against CKAP5 |
Tissue specificity |
Overexpressed in hepatomas and colonic tumors. Also expressed in skeletal muscle, brain, heart, placenta, lung, liver, kidney and pancreas. Expression is elevated in the brain.highly expressed in the Purkinje cell bodies of the cerebellum. |
Cellular localization |
CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeSpindle PoleSpindleChromosomeCentromereKinetochoreDetected On Centrosomes And Kinetochores During Interphase And Mitosis Independently From Tacc3 And ClathrinLocated To Spindle Poles And Microtubules During MitosisIn Complex With Tacc3 Localized To Microtubule Plus-Ends In Mitosis And InterphaseIn Complex With Tacc3 And Clathrin Localized To Inter-Microtubule Bridges In Mitotic SpindlesAccumulation Sites At Microtubule Plus Ends Protruded Approximately 100 Nm From Mapre1/Eb1 Sites In Interphase Cells |
Molecular weight |
Calculated: 218kDa/225kDa/226kDa. Observed: 250kDa |
Dilution range |
WB 1:500-1:2000 |
Alternative names |
Anti-Cytoskeleton-Associated Protein 5 antibodyAnti-Colonic And Hepatic Tumor Overexpressed Gene Protein antibodyAnti-Ch-Tog antibodyAnti-CKAP5 KIAA0097 antibody |
Protein name |
Cytoskeleton-Associated Protein 5Colonic And Hepatic Tumor Overexpressed Gene ProteinCh-Tog |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
|
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.