Anti-MKL1 antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Q969V6

The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants.

MRTFA

Rabbit polyclonal against MKL1

Cytoplasm
Nucleus
Subcellular Location Is Tightly Regulated By Actin Both In Cytoplasm And Nucleus: High Levels Of G-Actin In The Nucleus Observed During Serum Deprivation Lead To Low Levels Of Nuclear Mrtfa
While Reduced Levels Of Nuclear G-Actin Result In Accumulation Of Mrtfa In The Nucleus
G-Actin-Binding In The Cytoplasm Inhibits Nuclear Import By Masking The Nuclear Localization Signal (Nls)
In Contrast
Binding To Nuclear Globular Actin (G-Actin) Promotes Nuclear Export To The Cytoplasm
Nuclear Localization Is Regulated By Mical2
Which Mediates Depolymerization Of Nuclear Actin
Which Decreases Nuclear G-Actin Pool
Thereby Promoting Retention Of Mrtfa In The Nucleus And Subsequent Formation Of An Active Complex With Srf

WB 1:500-1:2000

Myocardin-Related Transcription Factor A
Mrtf-A
Mkl/Myocardin-Like Protein 1
Megakaryoblastic Leukemia 1 Protein
Megakaryocytic Acute Leukemia Protein

MRTFA_HUMAN