Anti-CBL antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

P22681

This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder.

CBL

Rabbit polyclonal against CBL

Calculated: 99kDa. Observed: 120kDa

Anti-E3 Ubiquitin-Protein Ligase Cbl antibody
Anti-Casitas B-Lineage Lymphoma Proto-Oncogene antibody
Anti-Proto-Oncogene C-Cbl antibody
Anti-Ring Finger Protein 55 antibody
Anti-Ring-Type E3 Ubiquitin Transferase Cbl antibody
Anti-Signal Transduction Protein Cbl antibody
Anti-CBL CBL2 RNF55 antibody

FOR RESEARCH USE ONLY (RUO).