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HER3 / ErbB3 Neutralizing Antibody

HER3 / ErbB3 Neutralizing Antibody

Item no.	10201-MA24-500
Manufacturer	Sino Biological
Amount	500ug
Category	Oncology Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Neural Adhesion Molecules Antibodies By Cell Type Carcinoma Hematology Lymphoma Melanoma Sarcoma Primary Antibodies Neuronal Cell Markers
Type	Antibody Monoclonal
Clone	MA24
Specific against	Human
Host	Mouse
Isotype	IgG1
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	sino
Available
Antigen molecule name	ERBB3
Storage	This antibody can be stored at 2C-8C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20C to -80C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Immunogen	Recombinant Human HER3 / ErbB3 Protein (Catalog#10201-H08H)
Purification	Protein A
Preparation	This antibody was obtained from a rabbit immunized with purified, recombinant Human HER3 / ErbB3 (rh HER3 / ErbB3; Catalog#10201-H08H; NP_001973.2; Met1-Thr643) and was produced using recombinant antibody technology.
Specificity	Human HER3 / ErbB3
Cross reactivity	Has cross-reactivity with Rhesus ErbB3 (90043-K08H) in ELISA assay
No cross-reactivity	No cross-reactivity with Mouse ErbB3 (51003-M08H) and Rat ErbB3 (80111-R08H) in ELISA assay.
Endotoxin	< 1.19 EU/mg
Buffer	0.2 um filtered solution in Histidine and Arginine buffer containing 120mM NaCl, 0.02% Tween 80, pH6.0
Block	This Erbb3 neutralizing antibody can block the binding of recombinant human NRG1-beta 1 Protein (11609-H01H2) to its recombinant receptor Erbb3 (10201-H08H).
Neutralization	The neutralization activity of Erbb3 neutralizing antibody is Measured by its ability to neutralize NRG1beta1/HRG1beta1induced proliferation in the MCF7 human breast cancer cell line. Recombinant Human NRG11beta1/HRG11beta1 stimulates proliferation in the MCF7 human breast cancer cell line. Proliferation elicited by Recombinant Human NRG11beta1/HRG11beta1 (40 ng/mL) is neutralized by increasing concentrations of Human ErbB3/Her3 Monoclonal Antibody (Catalog 10201-MA24).

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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